2020

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22 July 2020

The European Lead Factory selects first COVID-19 proposal

Over the last few months, as the world has grappled with the COVID-19 pandemic, the European Lead Factory has been looking for ways to contribute collective efforts and assets to help deal with the crisis. As part of this focus, we have decided to prioritise COVID-19 related proposals through a fast-track procedure. We're proud to announce that the first proposal to tackle the SARS-CoV-2 infection has now been selected. The screening program aims to identify small-molecule inhibitors of viral entry into host cells.

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22 July 2020

ELF project member spotlight: Sabine Mulders, PPSC

One of the objectives of the European Lead Factory (ELF) is to provide guidance to the drug discovery community on successful strategies in lead discovery techniques. Helping to achieve this objective is the Pivot Park Screening Centre (PPSC), the ELF partner responsible for assay development and high-throughput screening. To find out more about what’s involved in the assay development process and the interactions with researchers, we spoke to Sabine Mulders, Chief Project Officer at PPSC.

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16 June 2020

Cancer metabolism research bolstered by ELF collaboration

Metabomed, an Israeli biotech company that has been successful in progressing results through the European Lead Factory (ELF), has discovered a series of potent and selective inhibitors of ACSS2 (the AcetylCoA Short chain Synthase 2 enzyme) for the treatment of cancers dependent on acetate metabolism.

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10 June 2020

The power of innovative partnerships in driving drug discovery

Two scientists well-known within the European Lead Factory community, Peter Simpson and Graeme Wilkinson, recently published a paper discussing the features underpinning a successful drug discovery consortium.

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22 May 2020

In Memoriam: Professor dr. Huib Ovaa

Professor dr. Huib Ovaa, ELF Academic Chemistry Partner and Public Programme Owner passed away on the 19th of May 2020.

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15 May 2020

Study conducted in collaboration with ELF discovers brain compound can blur traumatic memories

An international team of researchers led by Leiden chemist Mario van der Stelt, have found that a naturally occurring compound in the brain, anandamide, contributes to the reduction of traumatic memories.

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12 May 2020

Project member spotlight: Patricia Kramer-Verhulst

In this, the first in a series of articles in which we introduce various members of the European Lead Factory (ELF) Consortium, we’re pleased to feature an interview with Patricia Kramer-Verhulst. Patricia is a member of the ELF Programme Office – a team of ELF project members at Lygature. We asked Patricia to explain her role and what it is that interests her most about the project.

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06 May 2020

ELF highlighted as part of IMI’s 12-year anniversary celebrations

In April, the Innovative Medicines Initiative (IMI) marked its 12th anniversary. To celebrate, it highlighted some of its early projects, one of which was the European Lead Factory (ELF). In several tweets and a special feature in the 100th edition of its newsletter, IMI reflected on the real-world impacts of the ELF project.

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23 April 2020

World Malaria Day: Raising awareness and celebrating progress

This Saturday is World Malaria Day. Marked each year on 25 April, the day is observed to raise awareness of the global burden of malaria and to celebrate the progress that has been made to combat it. This year, in the midst of the COVID-19 crisis, we are reminded of the importance of maintaining global prevention and control programmes to fight deadly infectious diseases like malaria.

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20 April 2020

The European Lead Factory and COVID-19

As the world grapples with the COVID-19 crisis, our European Lead Factory (ELF) Partners are working hard to contribute wherever they can to mitigate the impacts of the pandemic. At the same time, the ELF Consortium is looking for ways to contribute collective efforts and assets to help deal with the crisis.

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